The RET tyrosine kinase signaling pathway is involved in the development of endocrine resistant ER+ breast cancer.However, we know little about how ER+ cells activate RET signaling and initiate an endocrine resistant phenotype.Here we show that both ER+ endocrine resistant and sensitive breast cancers have a functional RET tyrosine kinase signaling
Metabolic aspects of low carbohydrate diets and exercise
Abstract Following a low carbohydrate diet, there is a shift towards more fat and less carbohydrate oxidation to provide energy to skeletal Event muscle, both at rest and during exercise.This review summarizes recent work on human skeletal muscle carbohydrate and fat metabolic adaptations to a low carbohydrate diet, focusing mainly on pyruvate dehy
Vortex-induced vibration energy harvesting with tandem square bluff bodies: Spacing ratio effects
The horizontal (L/D) and vertical H/D) spacing ratios of square bluff bodies are critical parameters influencing the efficiency of vortex-induced vibration (VIV) wind energy harvesting.This study investigates a tandem stationary square bluff body (SSBB) and a vibrating square bluff body under various spacing configurations using ANSYS/FLUENT simula
Performance Analysis and Improvement for CRUD Operations in Relational Databases from Java Programs Using JPA, Hibernate, Spring Data JPA
The role of databases is to allow for the persistence of data, no matter if they are of the SQL or NoSQL type.In SQL databases, data are structured in a set of tables in the relational database model, grouped in rows and columns.CRUD operations (create, read, update, and delete) are used to manage the information contained in relational databases.S